Physicians take care of patients, but they often ignore their own health. Physician burnout is highly associated with medical errors, quality of care [1-3], and career satisfaction [26 28 29] about one's career. One study found that, surgeons with work-home conflicts were more likely to have burnout, depression and less likely to recommend surgery as a career option to their children [29]. Burnout not only affects patient safety but more importantly physicians' health. Burnout is more prevalent among males, residents, and surgeons [4-9]. Previous studies focused on gender [10], age, medical errors [11 12], sleep deprivation, residents [4], the number of times on call per week [13], and specialties [26 28], but sometimes different results were obtained by different studies.. Hydration and nutritional status were acceptable. The patient showed. sensitivity.. Fig 3A and 3B represents the GAG/total protein of tibia and femur for MIA and ACLT groups, respectively. The results show that the GAG/total protein was significantly lower in tibia and femur in both intervention groups compared to the control group (p<0.05); however, in the intervention groups, the GAG/protein content was significantly lower in the femur than in tibia at both time points (p<0.05) (table 1 and 2). No significant difference was observed between week 1 and week 2 in the ACLT group, which indicates that ACLT has reached its maximal damaging effect as early as week 1 and this persisted till week 2. However, in the MIA group, the GAG/total protein content was significantly lower in week 2 compared to week1, indicating that considerable damage to the cartilage may have occurred at a relatively slower pace when OA is induced by this method. However, no significant difference was observed between the MIA and ACLT group at week 2, indicating similar extent of damage in both groups at the end of week 2. Nevertheless, the animal tissues in both intervention groups had significantly higher GAG/total protein level than that in the human OA tissue samples. In the human OA samples, the GAG/total protein level was significantly lower in the OA samples (3.1±0.7) as compared to the normal knees (13.5±2.5), indicating a relatively lower extracellular matrix components in the degenerated cartilage tissues (P<0.05) (Fig.3C).. We studied 22 patients with CHC and 20 healthy control subjects. Patients with persistently elevated serum aminotransferases and positive HCV RNA were included in the study. Patients with CHC underwent percutaneous liver biopsy. Serum level of L-FABP was determined by ELISA method.. care providers towards patient safety [6,12].. Conclusion.

Patients were contacted within 8 min of the 119 call (n = 6956) buy provigil south africa and were contacted between 8 and 16 min after the call (n = 6370). Further divided into groups in which the adrenaline was administered within/without 10 min after contact. Primary outcome was the rate of a good prognosis for cerebral performance (CPC1-2) at 1 month and secondary outcome was the return of spontaneous circulation (ROSC) rate.. Exercise is well known to cause oxidative pressure. In 1978, scientists first determined that physical exercise can lead to an increase in lipid peroxidation [27]. Other studies have shown that organ damage and lipid peroxidation appear in humans after a downhill run [28]. In our study, the 4-HNE lipid peroxidation marker was also observed in tissues through IHC staining (Fig. 3). In other research, the IHC results showed that 4-HNE-modified proteins accumulated in damaged muscle obtained from mice after acute running [23], which matches our findings. Our results showed that the organ damage scores were comparable with the percentages of 4-HNE-positive cells. For example, the damage scores for heart tissues were low and showed no significant (P < 0.05) differences between the E and E+D groups; the percentages of 4-HNE-positive cells also showed no significant (P < 0.05) differences in these groups (Fig. 2K and 3K). However, the organ damage scores showed that significantly (P < 0.05) damaged tissues such as the lung and kidney tissues also had higher percentages of 4-HNE-positive cells (Fig. 2M, 3M, 2N, and 3N). According to these results, tissue damage was positively correlated with lipid peroxidation. This also indicates that reactive oxygen species (ROS) play a role in exhaustive exercise-induced damage.. specialising in memory order provigil australia says.

We used a proteomic method to identify hypoxia-regulated proteins. The PowerBlot is an antibody-based Western array that can rapidly analyze the expression levels of many proteins at once. We selected 40 apoptosis-related proteins and determined that 22 of those proteins were significantly increased or decreased after hypoxia treatment. A summary of the PowerBlot expression data of proteins detected is listed in Table 1. Briefly, Bcl-x-28kD, caspase-3, caspase-7, Hsp70-64kD, PTEN, and JNK phosphor-specific showed 2.39-fold, 4.96-fold, 2.16-fold, 1.85-fold, 1.92-fold, and 2.29-fold increases of protein expression, respectively. Bag-1-29kD was only expressed after hypoxia treatment. On the other hand, Bad, pan-JNK/SAPK1-50kD, pan-JNK/SAPK-1-43kD, Bcl-2, Bid-21kD, and caspase-8 showed 1.92-fold, 2.21-fold, 2.17-fold, 1.91-fold, 9.40-fold, and 2.76-fold decreases of protein expression, respectively.. Resveratrol (RSVL) order provigil australia a nontoxic natural compound found in a wide variety of plants with known antioxidant and anti-inflammatory properties, is emerging as a potent chemopreventive and anticancer drug. Recently, we demonstrated that RSVL-induced apoptosis in several human cancer cell lines was associated with cleavage of the proapoptotic 116 kDa poly(ADP-ribose) polymerase protein (PARP) into its 89-kDa fragment.. Axillary brachial plexus block is a common regional anesthesia and peripheral nerve block technique in upper extremity surgery. It is very important to localize the nerve that shall be blocked and there are several ways to find the position of the nerves. Generally order provigil australia these methods are four major techniques named as sensation of paresthesia, anatomical landmarks, nerve stimulation and at last ultrasonography (1-6).. Suturing the BBAs is also a good choice. For example, in 2009, Vashu et al. treated two patients with intraoperative rupture of BBAs of the supraclinoid ICA, and after suturing, these two patients showed normal caliber vessels with no recurrence of BBAs during the follow-up [27]. In addition, the repair of BBAs with vascular closure staple clips is a similar technique to suturing. For example, in 2004, Yanagisawa et al. reported a study of a patient with a ruptured BBA and discussed that several attempts to apply various clips and repair the wall with sutures failed to close the tear; finally, the large tear of the ICA was repaired using vascular closure staple clips, which were placed as close to the edges of the tear as possible to avoid vessel narrowing; therefore, this procedure is useful for the urgent repair of an aneurysm tear [28].. give zero bio activation for wound.

Some of the following complications develop or become evident during labor or delivery:.

(3 μM with 0.1% DMSO, 48 h) and 0.1% DMSO as the control (Figure. uptake, enhanced fatty acid uptake and fatty acid oxidation, especially.

in down-stream of the polyol pathway have also been proposed to. after (or during, follow-up) long-distance running; 4) the outcome of.

Serum was isolated from patients' peripheral blood and stored in RNase/DNase-free tubes at -80℃ until RNA isolation. Total RNA containing small RNA was isolated from 500 μl of serum using mirVana isolation kit (Ambion) following the manufacturer's instructions with modifications. In brief, the collected serum was firstly mixed with Denaturing Solution containing 2-mercaptoethanol followed by the addition of Acid-Phenol/Chloroform and ethanol to precipitate total RNA and eluted in nuclease-free water. For small RNA isolation, total RNA was then incubated with miRNA Wash Solutions without pre-amplification and then eluted in appropriate volume of nuclease-free water. The samples were stored in -20℃ until use..

Benign biliary stricture can lead to biliary congestion and bile duct. The lack of differences between the centenarians and the autoimmune group and the similarities of both these groups compared with healthy controls should be further investigated. Our data are not sufficient to establish if the two groups are characterized by some of the same regulatory mechanisms. However, we can speculate that the observed lower expression of the miR-425-5p, miR-21-5p and miR-212-3p in centenarians could guarantee a lower level of inflammatory processes and this could be protective for several diseases. In centenarians this miRNAs pattern could protect against inflammation like in patients treated with glucocorticoids but without the negative effects of glucocorticoids. Another study suggests that miRNA deregulation, particularly mir-21-5p, may limit cardiovascular repair responses and result in an altered function and differentiation of cardiovascular progenitor cells and endothelial progenitor cells (EPCs), modulating endothelial regeneration and cardiomyocyte homeostasis and playing a crucial role in cardiovascular disease (CVD) [20]. This suggests the importance of studying the mechanism of the drugs on miRNAs because it could open new frontiers for the treatment of many diseases.. This curtailing of female reproduction commonly occurs between 45 and 55 years of age with worldwide estimates of average age at natural menopause varying from 44.6 years in Indian women from Punjab, 51.2 years in Polish and 52.0 years in French women.3,4 There has been evidence of shifting the natural menopause timing across Europe towards older ages, thereby confirming suggestions for secular trends.5

This curtailing of female reproduction commonly occurs between 45 and 55 years of age with worldwide estimates of average age at natural menopause varying from 44.6 years in Indian women from Punjab, 51.2 years in Polish and 52.0 years in French women.3,4 There has been evidence of shifting the natural menopause timing across Europe towards older ages, thereby confirming suggestions for secular trends.5.

Despite the fact that the above criteria are inadequate for identifying inappropriate use, a systematic review identified no studies that examined the judgment of the physicians in charge of patient consultations.3 The purpose of our study was to identify factors related to inappropriate ED use by comparing patients who sought medical care during regular consultation hours with those who visited EDs for out‐of‐hours care.. The serum levels of sICAM-1 in the T2DM subgroup were proportional to glucose (p< 0.05) and E-selectin (p< 0.05) levels order provigil australia and inversely related to HDL-cholesterol levels (p< 0.05). The concentrations of sVCAM-1 in the T2DM subgroup correlated significantly with triglyceride levels (p < 0.05). In addition, in this subgroup there was a significant, positive correlation between E-selectin and HOMA-IR values (p < 0.05) and significant negative correlation with HDL-cholesterol levels (p < 0.05). The CCL2 concentrations correlated with the BMI values in all subgroups of obese patients (p < 0.05). IL-10 levels correlated significantly negatively in the subgroup of T2DM patients with concentrations of E-selectin, CCL2 (p < 0.05), and of C-peptide (p < 0.05), and values of HOMA-IR (p < 0.05). In patients with type 2 diabetes and IFG, parameters characterizing the degree of obesity significantly, positively correlated with the levels of CRP (T2DM: BMI, body mass, fat mass, waist circumference; IFG: BMI, body mass, fat mass; p < 0.05). While the positive correlations in the NFG group were seen only between fat mass and CRP levels (p < 0.05). Moreover, CRP concentrations in T2DM subgroup correlated significantly with E-selectin levels (p < 0.05). In addition to the above-mentioned C-peptide concentrations in the T2DM subgroup correlated positively with the concentrations of triglycerides and CCL2 and E-selectin (p < 0.05).. Radiographic evaluations were routinely conducted every 3 weeks until 3 months postoperatively. We use the method which has been described by Pavlik by evaluating the vertical distance between the inferior border of the acromion and the clavicle in comparison with the contralateral side and measured the differences in millimeters (less than 2 mm, anatomical reposition; 2-4 mm, slight loss of reduction; 4-8 mm, partial loss of reduction; greater than 8 mm, total loss of reduction)[3]. Degenerative changes of the acromioclavicular joint was also reviewed and recorded.. Despite some limitations to this analysis, there are some recognizable strengths in our analysis. Guided by pre-defined eligibility criteria outlined by the PICOS, the SLR process involved highly sensitive searches of peer-reviewed literature, as well as searches of recent conferences and clinical trial registrations to identity any unpublished completed trials with results available. Although fixed-effects were used due to lack of trial data to generate a stable heterogeneity parameter, the thorough feasibility assessment acted as a way to decrease heterogeneity by removing trials that contained factors which would likely bias relative treatment effects. Traditional NMA reports pairwise HRs, which assumes that treatment effects do not vary over time. Although traditional NMAs were carried out, violations of the proportional hazards were observed for several treatments insinuating that pairwise HR results are not appropriate. The use of time-varying HR NMA rather than traditional NMA allowed for treatments to vary over time according to various fractional polynomial models. This is especially important for treatments that violated the proportional hazards assumption, such as the BRAF-inhibitors, which are known to rapidly lose efficacy after 6 months49. With the time-varying HR approach, relative treatment effects are represented by multiple parameters rather than a single parameter, thus allowing more flexibility necessary to accurately depict treatment efficacy over time.. In other multicenter phase III trial order provigil australia the efficacy of PFD was analyzed in patients with IPF and results shown in this trial suggested that, when 5 % change in VC was used as an index instead of the 10 % change, the efficacy of PFD could be evaluated with higher sensitivity and robustness over the 12-month study. It was also suggested that 5 % change in FVC at month 3 is clinically useful and a significant promising prognostic factor of IPF [19].. Activities order provigil australia Diet, Drug use and Sexual activity) screening with adolescents, starting with. Immune suppression therapy with oral prednisolone (40 mg/d from day 3) and mycophenolate mofetil (500 mg/d from day 14) was initiated, instead of cyclophosphamide pulse therapy, which the patient refused because of its possible carcinogenicity. The treatments resulted in drastic improvements both in the hypoalbuminemia and in the systemic edema (Figure 1C). At present, after treatment for 12 months with prednisolone (8 mg/d) and mycophenolate mofetil (2000 mg/d), the serum albumin level has stabilized over 4.0 g/dL without any clinical symptoms.

Immune suppression therapy with oral prednisolone (40 mg/d from day 3) and mycophenolate mofetil (500 mg/d from day 14) was initiated, instead of cyclophosphamide pulse therapy, which the patient refused because of its possible carcinogenicity. The treatments resulted in drastic improvements both in the hypoalbuminemia and in the systemic edema (Figure 1C). At present, after treatment for 12 months with prednisolone (8 mg/d) and mycophenolate mofetil (2000 mg/d), the serum albumin level has stabilized over 4.0 g/dL without any clinical symptoms..

Overall, the studies were determined to be of good quality and with minimal heterogeneity, although key differences were identified with respect to eligibility criteria, including melanoma sub-type and BRAF mutation status, intervention characteristics, and disease stage. Four trials were removed after the feasibility assessment, to ensure a homogenous evidence base: Caraceni 1998, CheckMate 238, Lian 2013, and EORTC 18952. Caraceni 1998 did not report any outcomes of interest, and therefore could not be included in the NMA. Lian 2013 was conducted exclusively in mucosal melanoma patients. Additionally, CheckMate 238 was largely conducted in a cutaneous melanoma patient population (85%), however, it did include small proportions of patients with acral, mucosal, and other melanoma sub-types. The rest of the evidence base was conducted in cutaneous melanoma patients. EORTC 18952 was conducted in stage IIB–IIIC patients and did not provide a stage III sub-group KM curve. The target population was stage III melanoma patients only. Therefore, trials conducted in stage III patients or that reported stage III sub-group analysis results were used in the NMA to ensure a homogenous evidence base.. is rather normally less. Therefore order provigil australia substantial magnification of the.

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I was digging through my toy chest the other day, looking for a spare TV remote, and I chanced upon a number of toys preserved from my childhood and, until that moment, forgotten. It was quite the trip down memory lane.

When I was around ten I loved order provigil australia, which were a line of plastic robot toys produced by buy provigil usa, which, in retrospect, were remarkably prescient of buy provigil online reddit. The franchise featured a somewhat-before-its-time storyline about a post-apocalyptic Earth in which two “races” of machines–“Destructors” and “Protectors”–vie for control of the planet. According to legend, both races were created by Man and left behind when he forsook the Earth’s surface, the Protectors to salvage, reconstruct, and protect the natural environment, and the Destructors to eliminate nasty mutants and aliens and other out-of-control beasties. In Man’s absence, the Destructors have taken over, enslaving the protectors and trying to blot out the memory of Man so they can rule without obligations. The Protectors keep the faith and do what they can to bring about the rebirth of Man, who is said to be concealed in hibernation in an ancient battle station. Most of the Starrior toys featured a tiny silver humanoid “pilot” figure apparently “riding” in the head which, in the story, was known as a “control chip.” These contained the essence of each Starrior–his or her robosoul, if you will. Supposedly the chips were shaped by Man in his image so that the Starriors would never forget their obligations to their Creator. Although the mini-comics that came with the toys were somewhat ambivalent on this point, if the control chips were scale replicas of human beings then the Starriors themselves were giant mecha by our standards.

In proper collect-them-all spirit, the packaging inserts listed all the available toys in the franchise, and I owned every one that was sold in the US, including the super-cool Armored Battle Station playset, for which I worked odd jobs to earn the necessary $20. The toys were not all released at once, with at least two “generations” appearing months apart and two particular toys, I recall vividly, never coming to market at all. These two were humanoid-type Starriors (known as “Wastors”) whose names were Flashfist and Bolar. Flashfist was a Protector and Bolar was a Destructor. They were listed and pictured in the packaging materials but never sold, a fact which frustrated me to no end. I even wrote a letter to Tomy asking when they would be released. I got some sort of canned response, as I recall.

One of the many cool things about the toys, in my opinion, was that the bits were interchangable. One could swap heads and arms and torsos and legs back and forth among the Wastors, and some of the other parts from the non-humanoid varieties. In truth there were few aesthetically satisfying combinations, however, as the colors from different toys tended to clash garishly and thus cause the hybrids to look exactly like what they were–bits and pieces of other toys stuck together. I experimented with lots of permutations before I discovered the red-and-black guy pictured below. I know I gave him a name, but I can’t now remember what it was. I do remember that I loved him intensely, and that I obsessed over him in a way that probably wasn’t healthy. I carried him around with me everywhere and would lose track of time staring at him from every angle, admiring the way all the bits fit together and complimented each other and considering myself pretty clever for having dreamed him up. He has the legs of Slaughter Steelgrave (the Destructor leader), the torso of Slice (a 2nd-gen Wastor with wind-up arm-weapon), and the arms and head of Saw-tooth (a 1st-gen Wastor with wind-up chest-weapon).


I remember quite clearly, when I was 11 or 12 years old, swearing to myself that when I grew old I would not put aside my toys and would continue to play with Starriors. They brought me so much happiness that I could not then bear the thought that I might ever part with them. In the end, of course, I did put them aside. They were dumped into a plastic barrel that lived in the attic of my parents’ house until I went off to college, and subsequently donated to charity when they moved out of that house. Only my little custom guy survived, and as an adult that seems right to me. Now, as a grown-up, I understand that the magic I experienced with these toys was not in the toys at all–it was in my head. And that’s why it’s right that the only one still with me is the one I made.

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I realized while meditating this evening that I tend to hold my shoulders up and forward. The guided progressive relaxation I use includes the instructions that the hands should lay “alongside the body, with the palms open toward the ceiling.” This position has always felt uncomfortable to me; my natural inclination has been to lie with my palms down against the bed. This is the position that feels most “relaxed” for me. When I tried to do it as instructed, I felt my arms uncomfortably twisted in a way that became downright infuriating after 45 minutes of motionless contemplation.

Tonight, in something of a breakthrough, I realized why. Rolling my shoulders in tends to bias my arms toward the palms-down position. If I really relax and stretch the muscles in my chest and put my scapulae flat against the bed, it becomes quite natural and comfortable to lie with my palms open to the ceiling, to say nothing of how it improves my experience of my chest and upper back. I have a barrel chest which, at least as an adolescent, looked pretty strange with my spindly limbs and neck, and I imagine the habit of pulling my shoulders forward was an unconscious effort to minimize this. It’s a habit that might also date to my bodybuilding days, as pulling the shoulders back tends to flatten and minimize the pecs whereas pulling them forward tends to bulge and emphasize the pecs, which, I am somewhat ashamed to admit, is something I once wanted to do.

I should think about ways to correct my habit, which I believe is both a lifting and a rounding of my shoulders. My father once told me (and now I wonder if he had an ulterior motive at the time) that he had corrected his own shoulder-rounding problem by having someone affix a piece of surgical tape across his upper back between his shoulder blades when they were in the proper position. Then if he started to pull them forward he would feel resistance and tightening in the tape and would be reminded to leave them back.

If I had somebody around here to apply the tape, I might just try that.

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He was the greatest professor I have ever known, and I’ve known a lot of them. I’ve just now heard of his passing this January.

I remember a physics class once, and the Russian professor was describing his reaction to textbook merchants touting the features of their latest, umpteenth, feature-packed editions.

“If you really want to make it great,” he would say to them, “Make it cost five dollars.”

Well, Bob Solomon did just that. I don’t know how long he taught his existentialism class, but he compiled the little eponymous blue textbook for it, and it did cost $5, and it’s one of the best damn books I’ve ever owned. Those lectures have been immortalized by purchase provigil from canada, and are available for sale as CDs or tapes. I can’t recommend them enough.

I remember in a lecture about Kierkegaard, Dr. Solomon drew a tiny stick figure at the bottom of the board, and next to it, towering over it, an enormous circle that one first assumes is going to be a planet. Then he draws a pupil and an iris and the circle becomes a cyclopean eye, staring down at the little man like a bug beneath a microscope.

“This,” he said, “is how Kierkegaard saw his relationship with God.”

It still makes me laugh.

When we read Camus, he talked about the sense of hopelessness as a doctor might describe an interesting pathology. “Everything you do,” he said, “becomes pointless if you think about it long enough. Even teaching. Every teacher has had the experience of a pupil who returns years later brimming with gratitude, and after talking to them for awhile, of realizing that they have completely and utterly missed the point.”

I never got to know Bob as well as I should have. I had the best grade in a class of 60 when I took his course, and the way was open for me. But I was too intimidated and I failed to establish a relationship with him. I asked for a meeting with him to write me a letter of recommendation for law school. He agreed, and then stood me up. He must’ve thought I’d missed the point, too. And at that time maybe I had.

But I quit law school. I never should have gone in the first place. I like to think that if I’d gone back and talked to Dr. Solomon, before he died, he would have been proud of me for realizing on my own that the world has too many damn lawyers in it, already. I like to think that, in the end, I didn’t miss the point at all.

Goodbye, Bob.

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Several years ago my mother bought a potted lemon tree and kept it out on the back porch. One day, she was surprised to notice a ripe, yellow, new-fallen lemon lying in the dirt in the pot. There were some small lemons growing on the tree, but they were green and much smaller than the one that had fallen, and that night when I was over for dinner she mentioned it to me.

Curious, I went outside to investigate the prodigious lemon. I squatted down to examine it, then poked a finger at it, and only then did I realize that I was looking at the cap of a mushroom and not a real lemon. Regrettably, I did not have the presence of mind to take a picture. The resemblence was truly uncanny. The photo I’ve included here gives an idea, perhaps, of how this mushroom, which is lepiota lutea, could be mistaken for a lemon in terms of color and general shape, but the one I saw in the flowerpot that morning was much more convincing.

At the time, I was astounded, convinced this was a deliberate evolutionary strategy by the mushroom–growing at the bases of trees and mimicking fallen fruit in order to trick herbivores into eating them and thus spreading the spores in their stool. As it turns out, lepiota lutea is commonly known as the “yellow houseplant mushroom” because it commonly turns up in all kinds of potted plants, for some reason. So expert opinion is against my hypothesis which, as the old Time-Life Books commercial used to say, is “dismissed as coincidence.” But part of me still wants to believe.

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Take all US troops out of Iraq and move them into Iran. The resulting power void in Iraq will leave the factions squabbling amongst themselves for control, and Iran will be too busy trying (and failing) to resist the US invasion to influence the process. Topple the Iranian government, destroy the infrastructure and all vestiges of WMD technology, administer free elections, and be done with it. At that point either bring the troops home or send them back to Iraq to knock over whatever maniac has seized power there in our absence, if he was not legitimately elected. Repeat the Iran-Iraq shuffle as necessary, until both nations get the point: We will not abide blind hatred and intolerance masquerading under the banner of religion, and especially not as a means of organizing a state.

If the Iraq debacle has proven anything, it’s that we’re really, really good at knocking over petty dictators and really lousy at installing democracies in their wake. So why not stick to what we do best? Knock ’em over and leave their nations to sort out their new governments for themselves. You can bet that whoever comes afterward will be, if not exactly grateful to, then at least respectful of US power.

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Breed yeasts to produce hexanol, rather than ethanol

In conventional fermentation, yeasts turn sugars into ethanol. Ethanol, as everyone knows, is promising as an alternative fuel. The problem is that yeasts die at concentrations higher than about 10% ethanol by weight, and so the fermentation process can at best produce alcohol that is 90% water. Obviously, this “beer” cannot be burned as fuel, and the excess water must be removed somehow, by distillation or adsorbtion, which adds a significant energy cost to each unit alcohol produced. At the earth’s equator, solar energy can be relied upon to make up this energy cost. At the more extreme latitudes, that’s not necessarily the case.

Ethanol is not the only alcohol produced in fermentation. Higher alcohols such as butyl, amyl, isoamyl, and 1-hexyl are also produced, albeit in trace concentrations. As a fuel alcohol, 1-hexanol has a lot going for it compared to ethanol. Firstly, it’s much “greasier” than ethanol, having a thrice-longer hydrocarbon tail, and thus will handle and burn much more like the hydrocarbon fuels we’re already using. Second and most importantly, however, unlike ethanol, 1-hexanol is *not* infinitely soluble in water, meaning that at some concentration the fuel and the water will simply phase-separate. Now, instead of having to spend energy to dry the alcohol, you just tap it straight out of the bioreactor at burnable concentrations.

The only reason we’re not doing this already is that (known) yeasts don’t produce useful concentrations of 1-hexanol. But because they’re microorganisms and they reproduce rapidly and in huge numbers it’s not inconceivable that they could be bred to do so. What’s needed is a rapid, colorimetric, quantitative assay for hexanol concentration so that thousands of individual yeast cultures can be rapidly screened in high-throughput equipment like plate readers. Without such an assay, chromatography of some sort is required, slowing the process of screening down by many orders of magnitude. With the right indicator, though, it would be possible to screen yeast cultures almost as fast as they could be selected and grown. A rate of 10000 generations per year is entirely reasonable. Note that 10000 generations is approximately the same “distance” that separates homo sapiens from neanderthals.

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Yesterday I’m walking home from school and I look up to see some strange guy in a hard hat at the far end of the block waving at me with his arm. I look around for a minute and see that there’s some kind of construction going on and I realize he wants me to cross to the other side of the street. So I do. But it miffs me a bit, because I dislike it when anyone assumes authority over me that’s not clearly theirs.

As I get near my condo, at 2529 Rio Grande, I realize what’s going on: They’re knocking down trees, and not little ones either. Just inside the stone wall which is all that remains of the seedy block of furnished apartments that used to occupy the lot immediately north of my building, stood these two proud 40-ft. oak trees, just to either side of the main gate. I don’t know how old they might have been, but I bet they predated the complex that was demolished around them. The workers have to clear the sidewalks because the branches are large and heavy and overhang them to some extent.

Now, I don’t know if it was because I was already a bit grumpy with these guys, or solely because I was offended at the casual destruction of the beautiful old trees in my neighborhood, but I decided I was going to make a hard time for these workers, if possible, and in the best situation maybe stop them from killing the trees. I’m not such a radical (or maybe brave) person as to strap myself to one of the trunks, and it didn’t really look like there would be time to make it to the hardware store and buy chain and a padlock for that purpose before they were finished, anyway.

So I did the only thing I knew to do, which was call the city. I know Austin has fairly tough municipal regulations regarding the felling of trees inside the city limits. I thought maybe I could at least verify that they had a permit to cut down these trees and get them stopped or at least fined if they didn’t. The woman who answered the city information line was confused by my request at first: “There’s a tree you want to cut down?” she said. “No,” I explained, “I’m concerned that I’m witnessing the illegal felling of a protected tree.” There was a pause, and then she said, “Hold on, I’ll have to ask about that one.” So I get the hold muzak, which is an impossibly banal counterpoint to the scene of arboreal slaughter outside my window. While I’m waiting on hold, the destruction of the first tree is completed and the excavator starts filling in the hole left by the torn-out roots.

Eventually the woman returns to the phone, and it’s clear that she now understands and appreciates my situation. “You need to speak to the City Arborist,” she tells me, and gives his name (which I never figured out how to spell, and hence will not include here), and his number, which is 512-974-1876. “I’m sorry it took so long for me to figure that out,” she says. I tell her it’s OK, and she thanks me for calling. It’s obvious at this point that she’s on my side.

I call the Arborist and get his answering machine. The excavator is now rumbling toward the second tree. I leave a rambling message about who and where I am and how they sure are beautiful trees and I just wanna make sure the workers are within their legal rights cutting them down. I am conflicted. A large part of me wants to go down and confront the workers, but I realize that will only make them defensive and will not stop them from doing what they’re doing. I pace back and forth for awhile and figure the only thing to do is take pictures so I can make sure they get punished if it turns out they’re breaking the law. So I snap a frame or two and turn back to the computer to work.

There’s a loud CRACK a minute or two later and I go back to the window and see that the excavator has broken a large limb off the second tree. About then the phone rings, and it’s the arborist, who, to my pleasure, sounds concerned and gets right to the point: “Tell me what you’re seeing,” he says. And I do. As I’m talking, the excavator repositions itself and strikes downward into the tree’s crotch, splitting the trunk, and I realize that there’s no stopping them at this point. I tell the arborist as much. “But I took pictures,” I explain, “in case it turns out that what they’ve done is illegal.”

“Where are you again?” he asks. “West Campus,” I tell him. “Do you know the neighborhood?” He doesn’t. “Do you have an address?” Apparently he’s got a database of some sort that lists permit-holders. I don’t know the exact address, but I can extrapolate from mine and take a guess: “Try 2601.” A minute later he comes back and says, “Yes, there’s a permit to develop that property,” which I understand from his disappointed tone to mean that there’s nothing to be done. Apparently the rule in Austin is that private homeowners need a permit to fell any tree with a diameter of 19 inches or greater, but that developers have more flexibility. The arborist can’t tell me what the specific site plan calls for with respect to these particular trees, but he can tell me that there is a plan and it’s been approved, so in all likelihood these guys are acting in accordance with it and hence within the bounds of law. I thank him and he thanks me, and before we hang up he asks me to call again any time I’m suspicious of tree-related crime, because his office depends almost completely on concerned citizens/nosy neighbors like me to catch and prevent the illegal destruction of trees. I assure him that I will.

And that’s where the story peters out. I wanted to do something but I didn’t, basically, and although I got some sympathetic voices on the phone none of it changes the basic fact of the matter, which is that there are now two muddy holes in the ground where there were once two live, beautiful, healthy trees. And I stood to one side and watched as a man with a machine tore them up. Should I have tried, physically, to intervene? Should I have obeyed that impulse to chain myself to the trunk? I don’t know the spirit of a tree, but I know how hard it was to watch them be destroyed. It was like a crime was happening out on the street, in broad daylight, and everyone was just walking by indifferently. I didn’t want to be the apathetic one; I wanted to be the one who gave a shit. But I tried to be a civilized adult about the whole thing and now I regret it. Even if I hadn’t, ultimately, saved those particular trees, a show of strength might’ve brought some attention to the subject, might’ve made the developers or the city authorities or whoever think twice the next time they decided to hire out that kind of a dirty job. But in the end I was just like everyone else: Too busy with my own concerns to take hours out of my day to worry about something as simple as the killing of a tree.